Study: CBGA beneficial against epileptic seizures

Cannabis certainly helps, to treat epileptic seizures. But which molecule is involved, exactly? A study by Australian researchers, published in the British Journal of Pharmacology and peer-reviewed, provides a preliminary answer. «Three cannabinoids have anticonvulsant properties: cannabigerolic acid (CBGA), cannabidivaric acid, and cannabigerovaric acid», as shown by this study conducted on mice.

The researchers started with a very simple observation. It was thought that the CBD was the most potent cannabinoid for treating epilepsy, as evidenced by the development about the drug Epidiolex. But this treatment is rarely used, «often due to its high price, limited availability, and, in some cases, a preference for extracts" »full spectrum," the scientists note. «Artisanal products that have varied cannabinoid profiles and often low CBD concentrations. This suggests that other cannabinoids may contribute to the anticonvulsant properties.».

The scientists therefore used mice that also suffered from seizures, whether induced artificially or occurring naturally. Various cannabinoids were then administered: CBG, CBDV, CBGA, CBGV, and THCV.

«The CBGA is the most powerful»

The «winners» are indisputable: « Cannabidivarine (CBDV), cannabidivaric acid (CBDVA), CBGA, and cannabigerovaric acid (CBGVA) have demonstrated anticonvulsant properties and significantly raise the temperature threshold at which seizures begin.», according to Australian researchers.

The CBGA is even «Potentially more potent than CBD and deserves more attention for its anticonvulsant potential», the researchers recommend. However, the drug is by no means a magic solution. In fact, these seizures are induced artificially. In cases of spontaneous seizures, CBGA is not a solution and may even prove dangerous. However, when used in conjunction with clobazam—a medication already used to treat epilepsy—it has proven effective for spontaneous seizures.

In conclusion, « »It appears that CBGA is not as versatile as CBD as an anticonvulsant, even though it is more potent for seizures caused by hyperthermia.". According to the scientists who worked on this study, the cannabis-based anticonvulsant treatment «It doesn't start and end with CBD; other cannabinoids will need to be considered in the future.».