What is CBD-HQ?
CBD-HQ is the abbreviation for Cannabidiol Hydroxy Quinone, a natural cannabinoid discovered by the professor Raphael Mechoulam from the Hebrew University of Jerusalem. The synthetic variant of CBD-HQ is also known as HU-331, short for Hebrew University 331. CBD-HQ is the result of CBD's natural oxidation process, with many potential therapeutic effects. It is derived from CBD's natural aging process.
CBD-HQ is a quinone variant of CBD. Quinones occur naturally and are produced when polyphenols oxidize in plants, a process similar to the oxidation of polyphenols when an apple is cut. On contact with oxygen, apple polyphenols are enzymatically oxidized into quinones, which give the characteristic brown color that appears when the apple is left out.

CBD-HQ molecule
CBD-HQ oxidation process
The oxidation process in an apple occurs in just a few minutes, whereas CBD takes much longer. CBD-HQ oxidation is a slow process that can take 10 to 15 years before CBD is fully converted to CBD-HQ.
Since the process of converting CBD into CBD Hydroxy Quinone is extremely time-consuming, its price is extremely high. The synthetic variant of CBD-HQ, also known as HU-331, is 1,000 times more expensive than gold.
Just like the CBN which is an oxidation product of THC, CBD Hydroxy Quinone is naturally present in very low concentrations in CBD-rich cannabis. CBD-HQ can be found in old hemp fibers and CBD-rich wool that have been in contact with open air for more than 5 years.
A new process was discovered following an experiment carried out in 2016 to remove the THC hemp fibre. There is a faster way to convert CBD naturally into CBD-HQ using pure oxygen under controlled conditions. It was found that, under ideal conditions, it was possible to convert over 50 % of CBD, in 3 weeks, into CBD-HQ. This discovery reduced the aging process by several years.


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